Complexity Science Seminar Series - Abstracts
Title:
Translating Pharmacogenomics and Biomedical-informatics of the Human OA-Atlas to Personalized Medicine
Presenter:
Prof. Ashok Amin, Carilion Clinic and Virginia Tech
Date and Time: Thursday, February 26th, 2009 3:30-4:30pm
Abstract:
At the dawn of the new millennium, the major challenge, we face is characterization of genes and symptoms involved in oligo-and polygenic disorders. Unlike monogenic diseases, pedigrees from complex diseases reveal no Mendelian inheritance patterns. Most human diseases are complex diseases with complex traits with multiple tissue/cell targets and are also influenced by lifestyles and environment. Hence, it is imperative to develop an "Atlas" capturing all the components of the disease. The present study described a "Whole-istic" approach using various forms of human tissues from tissue banks, DNA, RNA and protein technologies and biomedical informatics to scrutinize one such complex disease: Human Osteoarthritis {OA} (Attur et al 2002). This approach opens doors to "the third wave" in biomedical research and education in the coming decade. This advance has set a new platform for "big science" and translation research-integration and harmonization for basic science, clinical research, pharmacogenomics studies and biomedical-informatics for personalized medicine in the clinic for biomarkers and therapeutic targets for development (Amin et al 2007 and Amin 2008) The presentation will show the process involved in biomedical mathematics & informatics, computer science and inverse problems to distill the process to procure pragmatic data for clinical application (Amin and Wang, 2009). The presentation will also describe a similar systems approach to host parasite interactions of Pseudomonas in cystic fibrosis, identification of novel virulent apparatus modulating host-inflammation and biofilm formation. This methodology has become a cornerstone that can be applied to various biomedical and public health projects for personalized medicine.
References:
1. Attur MG, Dave MN, Akamatsu M, Katoh M and Amin AR (2002). "A System Biology" Approach to Bioinformatics and Functional Genomics in Complex Human Diseases: Arthritis. Current Issues in Molecular Biology 4: 129-146.
2. Amin AR, Seth Thompson & S. Amin.(2007). Future of Genomics in Diagnosis of Human Arthritis: the hype, hope and metamorphosis for tomorrow. Future Medicine, A Nature Publication. 2: 4-7.
3. Amin AR, (2008). Pleiotropic Effects of Statins in Inflammation: Friend or Foe in Human Arthritis. Future Medicine, 3 : 325-230
4. Amin AR and Wang G (2009) Identification and Characterization of Transcriptome-Based Biomarkers for Personalized Medicine in Arthritis and Cancer by Translational Genomics. In Biomedical Mathematics: Promising Directions in Imaging, Therapy Planning and Inverse Problems. Ed. Yair Censor, Ming Jiang, and Ge Wang. In Press.
Seminar Location: The seminars are held at:
Virginia Tech, Corporate Research Center
1880 Pratt Drive, Building XV
Seminar Room, First Floor
Directions: Map (PDF)
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