Seminars @ NDSSL

Title: Multiscale Stochastic Modeling and Simulation for Biochemical Systems

Presenter: Prof. Yang Cao Dept. Computer Science, Virginia Tech

Date and Time: Tuesday, October 2nd, 2007, 4:00-5:00PM

Abstract:

Biochemical systems are inherently multiscale and stochastic. In microscopic systems formed by living cells, the small numbers of reactant molecules can result in dynamical behavior that is discrete and stochastic rather than continuous and deterministic. In this talk I will start with an introduction of several biological systems that have motivated the research on stochastic modeling and simulation. Then I will focus on numerical solution of the chemical master equation (CME) and the corresponding Monte Carlo simulation techniques from Gillespie's stochastic simulation algorithm (SSA), a numerical simulation procedure that is essentially exact for chemical systems that are spatially homogeneous, to the state-of-art approximation methods including tau-leaping methods, hybrid methods and slow-scale SSA method. The multiscale nature of the underlying systems is to be discussed and several open challenging problems will be proposed for future research.

Seminar Location: The seminars are held at:
    Virginia Tech, Corporate Research Center
    1880 Pratt Drive, Building XV
    Seminar Room 2018, Second Floor
    Directions: Map (PDF)

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